wilforlide A
| Name | Wilforlide A | ||
| PubChem CID | 158477 | ||
| Molecular Weight | 454.7g/mol | ||
| Synonyms |
wilforlide A |
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| Formula | C₃₀H₄₆O₃ | ||
| SMILES | CC1(C2CCC3(C(C2(CCC1O)C)CC=C4C3(CCC5(C4CC6(CC5OC6=O)C)C)C)C)C | ||
| InChI | 1S/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1 | ||
| InChIKey | HHQJBWYXBWOFJY-YLXTXNMFSA-N | ||
| CAS Number | 84104-71-2 | ||
| ChEMBL ID | CHEMBL484424 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | LeiGongTeng | ||
| Use Part | Root, Leaf, Flower | ||
| Habitat | HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan, ChongQing | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Celastrales
-->Family: Celastraceae
-->Genus: Tripterygium
-->Species: Tripterygium wilfordii
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| Pair Name | Wilforlide A, Docetaxel | |||
| Partner Name | Docetaxel | |||
| Disease Info | [ICD-11: 2C82.0] | Prostate cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Down-regulation | Expression | CDKN1A | hsa1026 | |
| In Vitro Model | PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 |
| DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 | |
| In Vivo Model | These PC3-TxR cells were suspended in a 1:1 mixture of Matrigel and RPMI 1640 and subcutaneously implanted into planks of mice via injection. | |||
| Result | Wilforlide A was found to enhance the chemosensitizing effect of docetaxel both in vitro and in vivo. Further studies are warranted to verify wilforlide A as a new drug candidate to overcome docetaxel resistance in prostate cancer. | |||
